Causally upstream of, negative effect: Difference between revisions
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** Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known. | ** Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known. | ||
* '''What not to capture''' | * '''What not to capture''' | ||
** Relationships where the mechanism is known. These should be represented by other relationships. | ** Relationships where the mechanism is known. These should be represented by [https://wiki.geneontology.org/Annotation_Relations#Causal_Relations other relationships]. | ||
== Examples == | == Examples == | ||
Revision as of 14:23, 15 February 2023
Overview and Scope of Use
- This relation is used in GO-CAMs but not in standard annotation extensions.
- This relation is intended to represent a negative causal effect of one activity on another, where the mechanism is not known.
- The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
- the mechanism that relates the upstream activity to the downstream activity is not understood
- the upstream activity occurs before the downstream activity
- the upstream activity has a negative effect on the downstream activity
Annotation Usage Guidelines
- What to capture
- Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
- What not to capture
- Relationships where the mechanism is known. These should be represented by other relationships.
Examples
- TBD
Ontology Usage Guidelines
This relation is not used in the ontology.
Relations Ontology
causally upstream of, negative effect
Review Status
Last reviewed: February 8, 2023
Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken