Causally upstream of, negative effect: Difference between revisions
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== Overview and Scope of Use == | == Overview and Scope of Use== | ||
*The 'causally upstream of, negative effect' relation is used to relate | *This relation is used in GO-CAMs but not in standard annotation extensions. | ||
**the mechanism that relates the upstream | * This relation is intended to represent a negative causal effect of one activity on another, where the mechanism is not known. | ||
** | *The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when: | ||
** | **the mechanism that relates the upstream activity to the downstream activity is not understood | ||
**the upstream activity occurs before the downstream activity | |||
**the upstream activity has a negative effect on the downstream activity | |||
== Annotation Usage Guidelines == | == Annotation Usage Guidelines== | ||
* | * '''What to capture''' | ||
** Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known. | |||
* '''What not to capture''' | |||
*** What not to capture | ** Relationships where the mechanism is known. These should be represented by [https://wiki.geneontology.org/Annotation_Relations#Causal_Relations other relationships]. | ||
* | |||
== Examples == | |||
* | * There are currently no examples of when this relation would be used between two Molecular Functions, as for causal models, the curator should be able to choose a more specific relation. | ||
* | * If you have an example of when you'd like to use this relation, please bring the example to a GO Annotation conference call. | ||
== Ontology Usage Guidelines == | == Ontology Usage Guidelines == | ||
This relation is not used in the ontology. | |||
== Relations Ontology == | == Relations Ontology == | ||
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== Review Status == | == Review Status == | ||
Last reviewed: | Last reviewed: February 8, 2023 | ||
Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken | |||
[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations] | [http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations] |
Latest revision as of 08:54, 23 March 2023
Overview and Scope of Use
- This relation is used in GO-CAMs but not in standard annotation extensions.
- This relation is intended to represent a negative causal effect of one activity on another, where the mechanism is not known.
- The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
- the mechanism that relates the upstream activity to the downstream activity is not understood
- the upstream activity occurs before the downstream activity
- the upstream activity has a negative effect on the downstream activity
Annotation Usage Guidelines
- What to capture
- Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
- What not to capture
- Relationships where the mechanism is known. These should be represented by other relationships.
Examples
- There are currently no examples of when this relation would be used between two Molecular Functions, as for causal models, the curator should be able to choose a more specific relation.
- If you have an example of when you'd like to use this relation, please bring the example to a GO Annotation conference call.
Ontology Usage Guidelines
This relation is not used in the ontology.
Relations Ontology
causally upstream of, negative effect
Review Status
Last reviewed: February 8, 2023
Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken