Causally upstream of, negative effect

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Overview and Scope of Use

  • The 'causally upstream of, negative effect' relation is used to relate GO Biological Processes (BP) and/or GO Molecular Functions (MF) when:
    • the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is understood
    • the activities of the gene products in the upstream process occur before some event in the downstream process
    • the execution of the upstream event impinges on the downstream event by decreasing its execution

Annotation Usage Guidelines

  • Standard Annotation (This relation should not be used for standard annotations.)
    • Guidelines
      • What to capture
      • What not to capture
  • Examples
  • GO-CAM Annotation
    • Guidelines
      • What to capture
      • What not to capture
  • Examples

Ontology Usage Guidelines

Quality Control Checks

  • Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.(STILL NEEDS TO BE ENTERED)

Child Terms

Relations Ontology

causally upstream of, negative effect

Review Status

Last reviewed: October 31, 2022 David

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