Causally upstream of, negative effect

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Overview and Scope of Use

  • This relation is used in GO-CAMs but not in standard annotation extensions.
  • This relation is intended to represent a negative causal effect of on activity on another, where the mechanism is not known.
  • The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
    • the mechanism that relates the upstream molecular function to the downstream molecular function is not understood
    • the upstream molecular function occurs before the downstream molecular function
    • the upstream molecular function has a negativ3 effect on the downstream molecular function

Annotation Usage Guidelines

  • What to capture
    • Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
  • What not to capture
    • Relationships where the mechanism is known. These should be represented by other relationships.

Examples

  • mRNA decapping enzymes generally act on messages that repress translation and target them to P bodies for degradation. This is part of normal mRNA turnover in the cell and is not specific to individual RNAs. This process would be causally upstream and have a negative effect on the functions of the proteins encoded by the RNAs. reference link

Ontology Usage Guidelines

This relation is not used in the ontology.

Relations Ontology

causally upstream of, negative effect

Review Status

Last reviewed: October 31, 2022 David

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