Causally upstream of, negative effect

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Overview and Scope of Use

  • This relation is used in GO-CAMs but not in standard annotation extensions.
  • This relation is intended to represent a negative causal effect of one activity on another, where the mechanism is not known.
  • The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
    • the mechanism that relates the upstream activity to the downstream activity is not understood
    • the upstream activity occurs before the downstream activity
    • the upstream activity has a negative effect on the downstream activity

Annotation Usage Guidelines

  • What to capture
    • Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
  • What not to capture
    • Relationships where the mechanism is known. These should be represented by other relationships.


  • There are currently no examples of when this relation would be used between two Molecular Functions, as for causal models, the curator should be able to choose a more specific relation.
  • If you have an example of when you'd like to use this relation, please bring the example to a GO Annotation conference call.

Ontology Usage Guidelines

This relation is not used in the ontology.

Relations Ontology

causally upstream of, negative effect

Review Status

Last reviewed: February 8, 2023

Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken

Back to: Annotation Relations