View source for Causally upstream of, positive effect

== Overview and Scope of Use==
*This relation is used in GO-CAMs but not in standard annotation extensions.
* This relation links two activities when the first activity has a positive causal effect on the second activity, but the mechanism by which the two activities are linked is not known.
*The 'causally upstream of, positive effect' relation is used to relate two GO molecular functions when:
**the mechanism that relates the upstream activity to the downstream activity is not understood
**the upstream activity occurs before the downstream activity
**the upstream activity has a positive effect on the downstream activity

== Annotation Usage Guidelines==
* '''What to capture'''
** Relationships between molecular functions when a positive effect has been demonstrated but the mechanism is not known.
* '''What not to capture'''
** Relationships where the mechanism is known. These should be represented by [https://wiki.geneontology.org/Annotation_Relations#Causal_Relations other relationships].

== Examples==
* There are currently no examples of when this relation would be used between two Molecular Functions, as for causal models, the curator should be able to choose a more specific relation.
* If you have an example of when you'd like to use this relation, please bring the example to a GO Annotation conference call.

==Ontology Usage Guidelines==
This relation is not used in the ontology.

== Cross Reference to Relation Ontology (RO) ==
[http://www.ontobee.org/ontology/RO?iri=http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect]

== Review Status ==
Last reviewed: February 15, 2023

Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken


[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations]


[[Category: Relations]]
[[Category: GO-CAM Relations]]