Causally upstream of, positive effect: Difference between revisions
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== Overview == | == Overview == | ||
The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when the mechanism that relates the upstream process to the downstream process is known, and the activities of the gene products in the upstream process do not directly regulate the activities of the gene products in the downstream process. | The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when the mechanism that relates the upstream process to the downstream process is known, and the activities of the gene products in the upstream process do not directly regulate (i.e. regulate via a direct physical interaction) the activities of the gene products in the downstream process but are otherwise necessary for the downstream gene product to execute its function. | ||
=== Definition === | === Definition === |
Revision as of 14:02, 26 November 2018
Overview
The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when the mechanism that relates the upstream process to the downstream process is known, and the activities of the gene products in the upstream process do not directly regulate (i.e. regulate via a direct physical interaction) the activities of the gene products in the downstream process but are otherwise necessary for the downstream gene product to execute its function.
Definition
- Needs formal RO definition.
- Proposal: p is causally upstream of, positive effect on q if and only if p precedes q and p and q are linked in a causal chain whereby completion/execution/progression of p increases the frequency, rate or extent of q
- RO comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
Child Terms
Examples of Usage
- Regulation of transcription by a DNA-binding transcription factor activity results in increased levels of target mRNA. Expressed in a GO-CAM model, the transcription process of which the transcription factor activity is a part, has a causally positive effective that acts upstream of the activity of the target. In this case, the transcription factor does not directly regulate the activity of the target, but there is a known, causal process that links the activities of the transcription factor and the product of the transcribed gene.
- Exemplar GO-CAM model:http://noctua.geneontology.org/editor/graph/gomodel:5a5fc23a00000137
Quality Control Checks
Relations Ontology
causally upstream of, positive effect
Review Status
Last reviewed: November 26, 2018