Causally upstream of, positive effect: Difference between revisions

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== Overview ==
== Overview ==
*The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when:
*The 'causally upstream of, positive effect' relation is used to relate GO Biological Processes (BP) or GO Molecular Functions (MF) when:
**the mechanism that relates the upstream process to the downstream process or function is known
**the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is understood
**the activities of the gene products in the upstream process do not directly regulate (i.e. regulate via a direct physical interaction) the activities of the gene products in the downstream process but are otherwise necessary for the downstream gene product to execute its function
**the activities of the gene products in the upstream process occur before events in the downstream process
**in order for the downstream process to occur normally, the upstream process needs to occur


=== Definition ===
== Examples of Usage ==


*Needs formal RO definition and review of placement in hierarchy.
== Quality Control Checks ==
*Proposal: p is causally upstream of, positive effect on q if and only if p precedes q and p and q are linked in a causal chain whereby completion/execution/progression of p increases the frequency, rate or extent of q but not via a direct physical interacction between entities.
 
*RO comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y


=== Child Terms ===
=== Child Terms ===
== Examples of Usage ==
== Quality Control Checks ==


== Relations Ontology ==
== Relations Ontology ==
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== Review Status ==
== Review Status ==
 
Modified on Sept 26, 2022
Last reviewed: November 26, 2018
Last Reviewed: November 26, 2018


[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations]
[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations]

Revision as of 11:14, 26 September 2022

Overview

  • The 'causally upstream of, positive effect' relation is used to relate GO Biological Processes (BP) or GO Molecular Functions (MF) when:
    • the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is understood
    • the activities of the gene products in the upstream process occur before events in the downstream process
    • in order for the downstream process to occur normally, the upstream process needs to occur

Examples of Usage

Quality Control Checks

Child Terms

Relations Ontology

causally upstream of, positive effect

Review Status

Modified on Sept 26, 2022 Last Reviewed: November 26, 2018

Back to: Annotation Relations

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