Causally upstream of, positive effect

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Overview

The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function.

Definition

  • Needs formal RO definition.
  • Proposal: p is causally upstream of, positive effect on q if and only if p precedes q and p and q are linked in a causal chain whereby completion/execution/progression of p increases the frequency, rate or extent of q
  • RO comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

Child Terms

Examples of Usage

  • Regulation of transcription by a DNA-binding transcription factor activity results in increased levels of target mRNA. Expressed in a GO-CAM model, the transcription process of which the transcription factor activity is a part, has a causally positive effective that acts upstream of the activity of the target. In this case, the transcription factor does not directly regulate the activity of the target, but there is a known, causal process that links the activities of the transcription factor and the product of the transcribed gene.

Quality Control Checks

Relations Ontology

causally upstream of, positive effect

Review Status

Last reviewed: November 26, 2018

Back to: Annotation Relations