Causally upstream of, positive effect

Overview

• The 'causally upstream of, positive effect' relation is used to relate GO Biological Processes (BP) and/or GO Molecular Functions (MF) when:
  • the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is understood
  • the activities of the gene products in the upstream process occur before events in the downstream process
  • in order for the downstream process to occur normally, the upstream process needs to occur

Annotation Usage Guidelines

• Standard Annotation
  • What to capture
  • What not to capture
• GO-CAM Annotation
  • What to capture
  • What not to capture

Scope of Use

• Domain- Domain refers to the ontology terms that can be further specified with the relation.
• Range- Range describes the ontology terms that can be used to further specify the domain using the relation.

Usage Examples

• A peptidase activity that processes a signaling ligand.
  • http://noctua.geneontology.org/editor/graph/gomodel:632cf60a00000039

Quality Control Checks

• Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.

Cross Reference to Relation Ontology (RO)

causally upstream of, positive effect

Review Status

Reviewed on Sept 26, 2022 DavidH Reviewed on Oct 24, 2022 DavidH

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