Causally upstream of, positive effect

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Overview and Scope of Use

  • This relation is used in GO-CAMs but not in standard annotation extensions.
  • This relation is intended to represent a positive causal effect of on activity on another, where the mechanism is not known.
  • The 'causally upstream of, positive effect' relation is used to relate two GO Molecular Functions when:
    • the mechanism that relates the upstream molecular function to the downstream molecular function is not understood
    • the upstream molecular function occurs before the downstream molecular function
    • the upstream molecular function has a positive effect on the downstream molecular function

Annotation Usage Guidelines

    • What to capture
      • Relationships between molecular functions when a positive effect has been demonstrated but the mechanism is not known.
    • What not to capture
      • Relationships where the mechanism is known. These should be represented by other relationships.
    • Usage Examples

Ontology Usage Guidelines

  • This relation is not used in the ontology.


Quality Control Checks

  • Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.

Child Terms

positively regulates

constitutively upstream of

Cross Reference to Relation Ontology (RO)

causally upstream of, positive effect

Review Status

Reviewed on Nov 2, 2022 DavidH


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