Causally upstream of, negative effect

Overview and Scope of Use

• The 'causally upstream of, negative effect' relation is used to relate GO Biological Processes (BP) and/or GO Molecular Functions (MF) when:
  • the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is understood enough to know that the upstream process is not part of the downstream process
  • the activities of the gene products in the upstream process occur before some event in the downstream process
  • the execution of the upstream event impinges on the downstream event by decreasing its execution

Annotation Usage Guidelines

• Standard Annotation (This relation should not be used for standard annotations.)
  • Guidelines
    • What to capture
    • What not to capture
• Examples

• GO-CAM Annotation
  • Guidelines
    • What to capture
    • What not to capture
• Examples

Quality Control Checks

• Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.(STILL NEEDS TO BE ENTERED)

Child Terms

negatively regulates

removes input for

Relations Ontology

causally upstream of, negative effect

Review Status

Last reviewed: October 31, 2022 David

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