Causally upstream of or within, negative effect
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Overview and Scope of Use
- This relation is used in standard annotations.
- This relation links an activity to a biological process where the mechanism by which the activity affects the process is not known, but the directionality of the overall effect is negative.
- The 'causally upstream of or within, negative effect' relation links a Molecular Function to a Biological Process when:
- the mechanism that relates the activity to the process is not understood
- the activity has a negative effect on the process
Annotation Usage Guidelines
- What to capture
- Relationships between a molecular function and a biological process when a negative effect has been demonstrated but the mechanism is not known.
- What not to capture
- Relationships where the mechanism is known. These should be represented by causally upstream of, negative effect.
Examples of Usage
Last reviewed: March 16, 2023
Reviewed by: Pascale Gaudet, Kimberly Van Auken