Cell Cycle Content Meeting follow-up 27 March 2013

Meeting report

• Work through comments

Discussion items

• Merges of the checkpoint terms. To demerge or not.
• Regulation between checkpoint signaling and checkpoint response (signaling is_a positive regulation of response?)
• Regulation between checkpoint signaling and phase transition (signaling is_a negative regulation of phase transition?)
• Regulation between checkpoint and phase transition (checkpoint is_a negative regulation of phase transition?)

Merge of phase terms Previus e-mail from Jane

1. The relationship between the phases and other cell cycle processes. David OS has suggested that we could continue to use part_of, or when part_of is too strong use happens_during (also starts_during and ends_during). But I got the sense during the meeting that we wanted to steer away from using part_of between processes and phases and make the phases both is_a and part_of disjoint from the rest of bp? The main part_of children are currently the cell cycle transitions.

2. How to handle phases that are also processes. It's possible to frame some phases as processes, indeed some phases are defined this way e.g. metaphase. Would we want these to be represented under both 'cell cycle phase' and 'cell cycle process' and have two separate terms? Or do we decide which should be phases and which should be processes and just split them up?

3. Do we want to make this node generic for all phases in GO, and use it to house some of the e.g. developmental phases there? How might that look e.g.:

biological process ---[i] biological phase

---

[i] cell cycle phase

---

[i] developmental phase

etc

SF tickets

• regulation of CDK activity [1]