Constitutively upstream of

Overview and Scope of Use

• The 'constitutively upstream of' relation is used to relate GO Biological Processes (BP) and/or GO Molecular Functions (MF) when:
  • The mechanism that relates the upstream event (MF or BP) to the downstream event (MF or BP) is understood
  • The activities in the upstream event occur before events in the downstream event
  • The upstream event is required for the execution of the downstream event
  • The execution of the upstream event is approximately constant

Annotation Usage Guidelines

• Standard Annotation (This relation should not be used for conventional annotation)
  • Guidelines
    • What to capture
    • What not to capture
  • Examples

• GO-CAM
  • Guidelines
    • What to capture
      • This relation should be used when the nature of the activity of two gene products is understood and the first activity occurs relatively constantly and has a direct effect on the second activity. Examples of this would be enzymes that are needed for processing or maturation of a downstream enzyme or receptor, but do not have a direct effect on the receptor and are considered to be 'housekeeping' functions.
    • What not to capture
      • This relation should not be used to capture upstream activities that occur before a downstream activity, but aren't necessary for the downstream activity to occur.
  • Examples
    • PDI-6 encodes a protein disulfide isomerase that is required for proper folding of the receptor EGL-20. We understand what PDI-6 does, it is constitutive and if its activity is absent, EGL-20 is misfolded, degraded and cannot function. Link to reference
      • EGL-20 maturation - constitutively upstream of

Quality Control Checks

(STILL NEEDS TO BE ENTERED)

• Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.

Relations Ontology

constitutively upstream of

Review Status

Last reviewed: October 31, 2022

Back to: Annotation Relations