Directly positively regulates

WIP

Overview and Scope of Use

• The 'directly positively regulates' relation is used to relate two GO molecular functions when:
  • Two molecular functions act in direct succession (i.e. there is no intervening molecular function)
  • The upstream molecular function exerts its regulation on the downstream function by a direct effect on the enabler of the downstream function (i.e. the enabler of the downstream function is the substrate of the upstream function)
• Domain: Domain refers to the ontology terms that can be further specified with the relation.
  • GO molecular functions
• Range: Range describes the ontology terms that can be used to further specify the domain using the relation.
  • GO molecular functions

The 'directly positively regulates' relation is most commonly used between successive functions in a regulatory pathway, such as a signaling pathway.

Annotation Usage Guidelines

• Standard Annotation
  • 'directly positively regulates' should not be used for conventional annotations. It should instead be used in GO-CAM models.

• GO-CAM Annotation
  • 'directly positively regulates' should be used between successive Molecular Functions in GO-CAM models.
    • Usage Examples
      • Epidermal Growth Factor Receptor Signaling Pathway via MAPK Cascade (GO:0038029)
        • In the epidermal growth factor signaling pathway via MAPK cascade, a number of molecular functions directly positively regulate one another to transmit the presence of an external signal, an EGF ligand, through a number of successive downstream molecular functions to ultimately effect transcription of specific target genes.
        • Examples include the relationship between the receptor ligand activity and the epidermal growth factor receptor activity; the relationship between the guanine nucleotide exchange factor activity and the GTPase activity; and the relationships between the protein serine/threonine kinase activities of the MAPK cascade.
        • http://noctua.geneontology.org/editor/graph/gomodel:56d1143000000176

Ontology Usage Guidelines

• This relation is not used in the ontology.

Quality Control Checks

• Shex
  • https://github.com/geneontology/go-shapes/blob/master/shapes/go-cam-shapes.shex
  • Search this file for 'directly_positively_regulates'.

Child Terms

None

Cross Reference to the Relation Ontology (RO)

directly positively regulates

Review Status

Reviewed: Nov 22, 2022 Kimberly

Back to: Annotation Relations