Directly positively regulates

Overview and Scope of Use

• This relation is intended to represent a causal effect in which an upstream activity has a positive (increasing or activating) effect on an immediately downstream activity. Immediately means there is no intervening activity, i.e. it is generally through direct physical interaction. The upstream activity should be considered to be a mechanism for controlling the downstream activity, so the mechanism must be known. The 'directly positively regulates' relation is commonly used between successive functions in a regulatory pathway, such as a signaling pathway.
• The 'directly positively regulates' relation is used to relate two GO molecular functions when:
  • Two molecular functions act in direct succession (i.e. there is no intervening molecular function)
  • The upstream molecular function exerts its regulation on the downstream function by a direct effect on the enabler of the downstream function
  • The direct effect on the enabler enhances its ability to execute its function

Annotation Usage Guidelines

• Standard Annotation
  • 'directly positively regulates' should not be used as an annotation extension relation in conventional annotations. It should instead be used in GO-CAM models.

• GO-CAM Annotation
  • 'directly positively regulates' should be used between successive Molecular Functions in GO-CAM models.
    • Usage Examples
      • Epidermal Growth Factor Receptor Signaling Pathway via MAPK Cascade (GO:0038029)
        • In the epidermal growth factor signaling pathway via MAPK cascade, a number of molecular functions directly positively regulate one another to transmit the presence of an external signal, an EGF ligand, through a number of successive downstream molecular functions to ultimately effect transcription of specific target genes.
        • Examples include the relationship between the receptor ligand activity and the epidermal growth factor receptor activity; the relationship between the guanine nucleotide exchange factor activity and the GTPase activity; and the relationships between the protein serine/threonine kinase activities of the MAPK cascade.
        • http://noctua.geneontology.org/editor/graph/gomodel:56d1143000000176

Ontology Usage Guidelines

• This relation is not used in the ontology.

Quality Control Checks

• Shex
  • https://github.com/geneontology/go-shapes/blob/master/shapes/go-cam-shapes.shex
  • Search this file for 'directly_positively_regulates'.

Child Terms

None

Cross Reference to the Relation Ontology (RO)

directly positively regulates

Review Status

Reviewed: Nov 22, 2022 Kimberly

Back to: Annotation Relations