Directly positively regulates
WIP
Overview and Scope of Use
- The 'directly positively regulates' relation is used to relate two GO molecular functions when:
- Two molecular functions act in direct succession (i.e. there is no intervening molecular function)
- The upstream molecular function exerts its regulation on the downstream function by directly modifying the enabler of the downstream function (i.e. the enabler of the downstream function is the substrate of the upstream function)
- Domain: Domain refers to the ontology terms that can be further specified with the relation.
- GO molecular functions
- Range: Range describes the ontology terms that can be used to further specify the domain using the relation.
- GO molecular functions
The 'directly positively regulates' relation is most commonly used between successive functions in a regulatory pathway, such as a signaling pathway.
Annotation Usage Guidelines
- Standard Annotation
- 'directly positively regulates' should not be used for conventional annotations. It should instead be used in GO-CAM models.
- GO-CAM Annotation
- 'directly positively regulates' should be used between successive Molecular Functions in GO-CAM models.
- Usage Examples
- In the epidermal growth factor signaling pathway, a number of molecular functions directly positively regulate one another to transmit an external signal, the EGF ligand, through a number of successive downstream molecular functions that ultimately effect transcription of specific target genes.
Ontology Usage Guidelines
- This relation is not used in the ontology.
Quality Control Checks
- Shex
- https://github.com/geneontology/go-shapes/blob/master/shapes/go-cam-shapes.shex
- Search this file for 'directly_provides_input_for'.
Child Terms
None
Cross Reference to the Relation Ontology (RO)
Review Status
Reviewed: Nov 22, 2022 Kimberly
USAGE OF THIS RELATION HAS BEEN DEPRECATED
== Overview == The 'directly positively regulates' relation is used to relate two GO Molecular Functions whenever two Molecular Functions succeed one another directly, and the first regulates the activity of the second via a direct physical interactions. The 'directly positively regulates' relation is used to describe a relation, for example, between a ligand and the receptor that it activates. === Definition === Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. === Child Terms === == Examples of Usage == *In GO-CAM models, the 'directly positively regulates' relation is used for associations between two Molecular Functions. *In canonical Wnt signaling, a Wnt ligand 'directly positively regulates' the activity of a Frizzled receptor. * Examplar: http://noctua.berkeleybop.org/editor/graph/gomodel:56d1143000003025 == Quality Control Checks == == Relations Ontology ==
Review Status
Last reviewed: August 8, 2019