Directly positively regulates
Overview and Scope of Use
- The 'directly positively regulates' relation is used to relate two GO molecular functions when:
- Two molecular functions act in direct succession (i.e. there is no intervening molecular function)
- The upstream molecular function exerts its regulation on the downstream function by a direct effect on the enabler of the downstream function
- Domain: Domain refers to the ontology terms that can be further specified with the relation.
- GO molecular functions
- Range: Range describes the ontology terms that can be used to further specify the domain using the relation.
- GO molecular functions
The 'directly positively regulates' relation is most commonly used between successive functions in a regulatory pathway, such as a signaling pathway.
Annotation Usage Guidelines
- Standard Annotation
- 'directly positively regulates' should not be used for conventional annotations. It should instead be used in GO-CAM models.
- GO-CAM Annotation
- 'directly positively regulates' should be used between successive Molecular Functions in GO-CAM models.
- Usage Examples
- Epidermal Growth Factor Receptor Signaling Pathway via MAPK Cascade (GO:0038029)
- In the epidermal growth factor signaling pathway via MAPK cascade, a number of molecular functions directly positively regulate one another to transmit the presence of an external signal, an EGF ligand, through a number of successive downstream molecular functions to ultimately effect transcription of specific target genes.
- Examples include the relationship between the receptor ligand activity and the epidermal growth factor receptor activity; the relationship between the guanine nucleotide exchange factor activity and the GTPase activity; and the relationships between the protein serine/threonine kinase activities of the MAPK cascade.
- http://noctua.geneontology.org/editor/graph/gomodel:56d1143000000176
- Epidermal Growth Factor Receptor Signaling Pathway via MAPK Cascade (GO:0038029)
- Usage Examples
- 'directly positively regulates' should be used between successive Molecular Functions in GO-CAM models.
Ontology Usage Guidelines
- This relation is not used in the ontology.
Quality Control Checks
- Shex
- https://github.com/geneontology/go-shapes/blob/master/shapes/go-cam-shapes.shex
- Search this file for 'directly_positively_regulates'.
Child Terms
None
Cross Reference to the Relation Ontology (RO)
Review Status
Reviewed: Nov 22, 2022 Kimberly