Provides input for

Overview

• The 'directly provides input for' relation is used to relate two GO Molecular Functions when:
  • Two Molecular Functions succeed one another directly
  • The output of the first molecular function is an input of the second Molecular Function.

The 'directly provides input for' relation is most commonly used between successive steps of a metabolic pathway.

Annotation Usage Guidelines

• Standard Annotation
  • 'directly provides input for' should not be used for conventional annotations. Instead its use should be reserved for GO-CAM models.

• GO-CAM Annotation
  • 'directly provides input' should be reserved to related successive Molecular Functions in GO-CAM models.
  • Usage Examples
    • In glycolysis, triose phosphate isomerase activity (MF) 'directly provides input for' glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (MF).
      • triose phosphate isomerase activity converts dihydroxyacetone phosphate (input) to glyceraldehyde-3-phosphate (output) as part of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase converts glyceraldehyde-3-phosphate (input) to 3-phosphonato-D-glyceroyl phosphate(4−) (output).
      • http://noctua.geneontology.org/editor/graph/gomodel:632cf60a00000208
    • A glucose tansmembrane transporter activity (MF) 'directly provides input for' lactose synthase activity (MF).
      • • cytosolic glucose (input) is transported across the Golgi membrane to become Golgi-lumenal glucose (output). In the Golgi lumen the Golgi-lumenal glucose (input) is converted into lactose (output).
        • http://noctua.geneontology.org/editor/graph/gomodel:632cf60a00000239?

Scope of Use

• Domain: Domain refers to the ontology terms that can be further specified with the relation.
  • GO Molecular Functions
• Range: Range describes the ontology terms that can be used to further specify the domain using the relation.
  • GO Molecular Functions

Quality Control Checks

• Shex
  • https://github.com/geneontology/go-shapes/blob/master/shapes/go-cam-shapes.shex
  • Search this file for 'directly_provides_input_for'.

Cross Reference to the Relation Ontology (RO)

directly provides input for

Review Status

Reviewed: May 11, 2018

Reviewed: September 27, 2022 DavidH

Reveiwed: October 26, 2022 DavidH

Back to: Annotation Relations