Examples new GO term requested
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1. negative regulation of neuron death in response to H<sub>2</sub>O<sub>2</sub>
PMID:15983381 demonstrates that DJ-1 (Q99497, PARK7) protects against oxidative stress-induced neuron cell death.
Statement from paper:
''wild-type DJ-1 sequesters Daxx in the nucleus, prevents it from gaining access to the cytoplasm, from binding to and activating its effector kinase apoptosis signal-regulating kinase 1, and therefore, from triggering the ensuing death pathway''
{| class="wikitable" border="1"
|-
! Folded/unfolded
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
! Parent terms of new folded GO term
|-
| Unfolded - NOT created as no suitable relationship available
| Q99497 <span style="color:green">PARK7 (DJ-1)</span>
| GO:1901215 <span style="color:green">negative regulation of neuron death</span>
| PMID:15983381
| IDA
| No suitable relationship available (GO:0070301 <span style="color:green">cellular response to hydrogen peroxide</span>)
|
|-
| Folded - created using a NEW GO term rather than the annotation extension field
| Q99497 <span style="color:green">PARK7 (DJ-1)</span>
| New GO term created <span style="color:green">Negative regulation of neuron death in cellular response to hydrogen peroxide</span>
| PMID:15983381
| IDA
|
| is_a <span style="color:red">negative regulation of neuron death</span> AND is_a <span style="color:red">cellular response to hydrogen peroxide</span>
|-
| Unfolded annotation NOT appropriate
| Q99497 <span style="color:green">PARK7 (DJ-1)</span>
| GO:1901215 <span style="color:green">negative regulation of neuron death</span>
| PMID:15983381
| IDA
| part_of (GO:0070301 <span style="color:green">cellular response to hydrogen peroxide</span>)
|
|-
| Folded creates part_of instead of is_a parent relationships
| Q99497 <span style="color:green">PARK7 (DJ-1)</span>
| New GO term created <span style="color:green">negative regulation of neuron death INVOLVED_IN cellular response to hydrogen peroxide</span>
| PMID:15983381
| IDA
|
| is_a <span style="color:red">negative regulation of neuron death</span> AND part_of <span style="color:red">cellular response to hydrogen peroxide</span>
|}
'''The curator considered applying the relationship part_of but this would have led to cellular response to hydrogen peroxide having a part_of relationship to the new annotation extension GO term, when what was required was an is_a relationship.'''
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Review Status
Last reviewed: September 27, 2021