Enables: Difference between revisions

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== Overview ==
== Usage guidelines ==
The 'enables' relation is used to relate a gene or gene product to a GO Molecular Function, e.g. MAPK1 enables protein kinase activity.  This indicates that the MAPK1 gene product executes the protein kinase activity..
===What to capture with the has_input relation===
=== Definition ===
* The <code>enables</code> relation is used to relate a gene or gene product to a GO Molecular Function. A gene product <code>enables</code> a Molecular function if it can perform the reaction on its own. The <code>enables</code> relation can be used for members of complexes if the activity is mediated by that gene products and other subunits are accessory.
* 'enables' is considered the default relation between a gene or gene product and a Molecular Function.


=== Child Terms ===
===What not to capture===
* Only gene products that mediate a Molecular Function should be annotated with the <code>enables</code> relation.
* Accessory subunits should not be annotated to a Molecular Function in which they do not directly participate. These can usually be assigned other activities such as <code>GO:0060090 molecular adaptor activity</code> or <code>GO:0098772 molecular function regulator activity</code>
* See [[Contributes_to]] documentation for activities mediated by multiple gene products.


== Examples of Usage ==
==Usage examples for the enables relation==
*In gene annotation files, the 'enables' relation is used for all associations between a gene or gene product and a Molecular Function.
 
* MAPK1 enables protein kinase activity.  This indicates that the MAPK1 gene product executes the protein kinase activity.


*[https://www.ncbi.nlm.nih.gov/pubmed/17996703 Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.]
*[https://www.ncbi.nlm.nih.gov/pubmed/17996703 Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.]
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* Examplar: http://noctua.berkeleybop.org/editor/graph/gomodel:5323da1800000002
* Examplar: http://noctua.berkeleybop.org/editor/graph/gomodel:5323da1800000002
** Inferred GPAD: http://noctua.berkeleybop.org/workbench/annpreview/?model_id=gomodel:5323da1800000002
** Inferred GPAD: http://noctua.berkeleybop.org/workbench/annpreview/?model_id=gomodel:5323da1800000002
== Quality Control Checks ==


== Relations Ontology ==
== Relations Ontology ==
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== Review Status ==
== Review Status ==
Last reviewed: May 11, 2018


Last reviewed: May 11, 2018
[http://wiki.geneontology.org/index.php/Annotation_Relations Back to: Annotation Relations]


[http://wiki.geneontology.org/index.php/Biological_Process Back to: Biological Process]


[[Category: Annotation]]
[[Category: Relations]]
[[Category: Gene Product to Term Relations]]
[[Category: Gene Product to Term Relations]]

Revision as of 09:32, 9 February 2022

Usage guidelines

What to capture with the has_input relation

  • The enables relation is used to relate a gene or gene product to a GO Molecular Function. A gene product enables a Molecular function if it can perform the reaction on its own. The enables relation can be used for members of complexes if the activity is mediated by that gene products and other subunits are accessory.
  • 'enables' is considered the default relation between a gene or gene product and a Molecular Function.

What not to capture

  • Only gene products that mediate a Molecular Function should be annotated with the enables relation.
  • Accessory subunits should not be annotated to a Molecular Function in which they do not directly participate. These can usually be assigned other activities such as GO:0060090 molecular adaptor activity or GO:0098772 molecular function regulator activity
  • See Contributes_to documentation for activities mediated by multiple gene products.

Usage examples for the enables relation

  • MAPK1 enables protein kinase activity. This indicates that the MAPK1 gene product executes the protein kinase activity.

Relations Ontology

enables

Review Status

Last reviewed: May 11, 2018

Back to: Annotation Relations