Heart Development workshop (Archived): Difference between revisions

From GO Wiki
Jump to navigation Jump to search
Line 104: Line 104:


== Relevant papers and other resources ==
== Relevant papers and other resources ==
'''Zebrafish papers'''


Recent review on signaling involved in development of the second heart field - '''[http://www.ncbi.nlm.nih.gov/pubmed/19390062?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PMID:19390062] '''
Recent review on signaling involved in development of the second heart field - '''[http://www.ncbi.nlm.nih.gov/pubmed/19390062?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PMID:19390062] '''
Line 114: Line 115:


Good cartoon of zebrafish heart anatomy - '''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&dopt=Abstract&term=11505366 PMID:11505366]'''
Good cartoon of zebrafish heart anatomy - '''[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=PubMed&dopt=Abstract&term=11505366 PMID:11505366]'''


'''[http://www.indiana.edu/~anat550/cvanim/index.html Cardiovascular Embrology Animations]'''
'''[http://www.indiana.edu/~anat550/cvanim/index.html Cardiovascular Embrology Animations]'''

Revision as of 19:37, 31 August 2009

Return to GOC Main Page

Return to Cardiovascular Main Page

Please suggest agenda items, relevant papers and other information relating to heart development GO terms that you would like discussed at this workshop, to enable us to form an agenda.



Participants

BHF-UCL GO annotators

Dr Varsha Khodiyar

Dr Ruth Lovering


GO Editors

Dr Tanya Berardini

Dr David Hill

Dr Doug Howe


Heart Development Experts

Professor Shumo Bhattacharya

Professor Pete Scambler

Dr Ross Breckenridge

Dr Paul Riley


Flybase GO annotator

Dr Susan Tweedie

Programme

Location - 4th Floor seminar room, Rayne Institute map

Timing - 9am - 6pm


Specification of cardiac precursor tissues and cells

* Development of primary and secondary heart fields
* cardiac muscle cell specification/differentiation/development 
* cardiac endothelial cell specification/differentiation/development

Cardiac cell migration, morphogenesis of the heart

* morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube
* L/R patterning
* neural crest contribution to the heart

Formation of heart structures

* heart chamber, septum, trabeculae, valves
* How much anatomy should we include in GO?

Cardiac conduction

* development of the electrical signaling systems of the heart
* function of conduction system
* Cardiac Conduction terms - SF tracker ID: 2531687

Blood vessel development?

* blood composition?

Current Heart Development Ontology Terms

The currently available heart development process ontology can be viewed here chart (May 2009)

The 38 GO IDs used to create this graph:

GO:0001947 GO:0003007 GO:0007507 GO:0007510 GO:0007512 GO:0007513 GO:0010002 GO:0035050 GO:0035051 GO:0035052 GO:0035053 GO:0035054 GO:0042684 GO:0042685 GO:0048738 GO:0048739 GO:0055003 GO:0055004 GO:0055005 GO:0055006 GO:0055007 GO:0055008 GO:0055009 GO:0055010 GO:0055011 GO:0055012 GO:0055014 GO:0055015 GO:0055017 GO:0060038 GO:0060214 GO:0060317 GO:0060347 GO:0060379 GO:0060411 GO:0060412 GO:0060413 GO:0060419


heart morphological structure development (19 terms) chart:

GO:0001947 GO:0003007 GO:0007507 GO:0007512 GO:0035050 GO:0035054 GO:0048738 GO:0048739 GO:0055008 GO:0055009 GO:0055010 GO:0055017 GO:0060214 GO:0060317 GO:0060347 GO:0060411 GO:0060412 GO:0060413 GO:0060419


differentiation of specific cardiac cell types (20 terms) chart:

GO:0007510 GO:0007513 GO:0010002 GO:0035051 GO:0035052 GO:0035053 GO:0042684 GO:0042685 GO:0055003 GO:0055004 GO:0055005 GO:0055006 GO:0055007 GO:0055011 GO:0055012 GO:0055014 GO:0055015 GO:0060038 GO:0060317 GO:0060379

Suggested Agenda Items

  • Development of primary and secondary heart fields (Doug)
  • morphogenic and migratory changes to those cell populations as they move towards formation of the heart tube (Doug)
  • L/R patterning (Doug)
  • cardiac muscle cell specification/differentiation/development (Doug)
  • development of the electrical signaling systems of the heart (Doug)
  • neural crest contribution to the heart (David)
  • specific terms we need to incorporate into the ontology (Varsha)

- atrioventricular conduction (PMID:10587520 for annotation of NKX2-5 P52952)

- septum secundum development (PMID:10587520 for annotation of NKX2-5 P52952)

Relevant papers and other resources

Zebrafish papers

Recent review on signaling involved in development of the second heart field - PMID:19390062

Differences in cardiomyocyte differentiation b/t mice and zebrafish - PMID:19395641

Zebrafish mutants affecting several aspects of heart tube development and morphogenesis - PMID:16319113

Review of Zebrafish heart development, covers L/R patterning, morphogenesis - PMID:16319113

Good cartoon of zebrafish heart anatomy - PMID:11505366


Cardiovascular Embrology Animations

Mouse Anatomy Browser - Heart

Notes

1. Cardiac muscle cell development was covered by the muscle group, but it won't hurt to give it a review (David)

2. In GO, heart does indeed refer to the dorsal vessel of arthropods, but I'm not sure we will have time to cover it in this meeting other than to make sure we are not inconsistent with the representation of its development (David)