Indirectly positively regulates

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Revision as of 11:40, 1 February 2023 by Vanaukenk (talk | contribs) (Created page with "== Overview and Scope of Use== * The 'indirectly positively regulates' relation is used to relate GO Molecular Functions (MF) when: ** The upstream activity occurs before the downstream activity, but there are intervening activities between them (indirect) ** The mechanism that relates the upstream activity to the downstream activity is understood ** The upstream activity promotes execution of the downstream activity (positive) ** Execution of the upstream activity is co...")
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Overview and Scope of Use

  • The 'indirectly positively regulates' relation is used to relate GO Molecular Functions (MF) when:
    • The upstream activity occurs before the downstream activity, but there are intervening activities between them (indirect)
    • The mechanism that relates the upstream activity to the downstream activity is understood
    • The upstream activity promotes execution of the downstream activity (positive)
    • Execution of the upstream activity is conditional (regulation)

Annotation Usage Guidelines

  • Standard Annotation (TBD - curators could use this to relate MF to MF, but will they want to? Do we need this?)
    • Guidelines
      • What to capture
      • What not to capture
    • Examples
  • GO-CAM
    • Guidelines
      • What to capture
        • This relation is typically used for MFs that are part of activity-regulating BPs, e.g. regulation of gene expression and its children, that increase expression and thus, activity, of the downstream target.
      • What not to capture
        • Indirectness indicates that there are intervening activities, e.g. general transcription factor activities or polymerases, between the two activities connected with this relation. Since the intervening activities may be part of a larger coordinated process of gene expression, it is not necessary for curators to model the entire coordinated process in their GO-CAM.
    • Example

Quality Control Checks

  • Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.

Child Terms

Relations Ontology

indirectly positively regulates

Review Status

Last reviewed: February 1, 2023


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