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| * Phenote testing (Melissa, Amina, who else?) | | * Phenote testing (Melissa, Amina, who else?) |
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| Return to [[Consortium_Meetings]]
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| =Agenda=
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| '''ALERT:''' GO Top needs to sign off on agenda prior to these meetings. If there is no action item, or discussion point proposed in advance, the meeting is not the forum for first initiating a discussion.
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| ==Action Items==
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| http://wiki.geneontology.org/index.php/SLC_GO_Consortium_Meeting_Minutes_April_2008#ACTION_ITEMS
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| ==Ontology Content Development==
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| ===Work in progress===
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| *MF-BP links : [[Function-Process_Links]]
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| ** (Note from the managers' meeting: Chris has been updating the wiki pages; we should probably organize that by 'types' of links to be adding; this also involves the new relations to be added)
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| ** Outline of scope of project, progress report (Chris, ~25 slides)
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| *** relations to be used - [[part_of]], [[has_part]] and [[regulates]]
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| *** Implementation plan
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| *** [[Mining_function_process_links_from_pathway_databases|Automatically extracting links from pathway databases]]
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| ** Manually curated links - pilot projects (Jennifer, Harold)
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| :The electron transport working group have been discussing this issue in depth. We present our conclusions. In brief, our proposal is that links between function and process should only be made when we can use part_of (rather than has_part) or when there is a single step process term. (Jennifer presenting 29 [http://cvsweb.geneontology.org/cgi-bin/cvsweb.cgi/go/meeting/consortium/Montreal2008/FunctionProcessLinksPhotosynthesisJDeegan.ppt Slides])
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| : Various intermediary Metabolism MF-BPs (Harold [20 slides http://wiki.geneontology.org/index.php/Image:FXP-HJD-GOC_Montreal-reduced.pdf])
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| :*Plans to add regulates relationships within the molecular function (MF) ontology, and between MF and BP (David, Tanya, Chris) -- this is now covered
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| *[[Ontology_Quality_Control|Ontology content QC]]
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| **Ongoing regulation-term QC (David, Tanya, Chris) - think this is covered?
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| **[[:Category:Cross Products]] - use of XP defs and logical reasoning to do QC. See [[XP:Progress 2008]]. (~5 slides, Chris)
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| *"Trigger" files for annotation QC - first set based on taxon correlation (Jennifer, Chris)(Jennifer presenting 11 [http://cvsweb.geneontology.org/cgi-bin/cvsweb.cgi/go/meeting/consortium/Montreal2008/AnnotationQCJDeegan.ppt Slides])
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| *[[Signaling|Signal transduction]] - New high level term proposal (Jennifer, David)
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| :Jennifer and David have been working on a proposal for a new set of high level signaling terms. The new terms are ready to go live and we present them for comment. (~5 min talk) [http://cvsweb.geneontology.org/cgi-bin/cvsweb.cgi/go/meeting/consortium/Montreal2008/SignalingProposalJDeegan.ppt Slides]
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| *[[Cellular_component_processes|Processes affecting cellular components]], e.g. CC organization and biogenesis (Midori, Jane, David?)
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| *PAMGO collaboration - brief report on new term additions and QC (Jane)
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| *Collaboration with IMG to map to IMG terms to GO terms (Jane)
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| *[[Proteases|Peptidase activity terms]] - reorganization completed
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| ===Ontology development discussion topics===
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| *Setting priorities across different types of content development task
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| **How to allocate effort among (a) overall logical enhancements (e.g. improving genus-differentia aspects of definitions or adding new relationship types); (b) keeping up with SF submissions; (c) content meeting changes; anything else
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| **More generally, what's the right balance between retrofitting the existing ontology (definition style, relationship types just two examples) versus new additions?
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| ===OBO-Edit===
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| * Update on latest version (Amina)
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| ** Using Reasoner and Cross-product definitions for Ontology QC and automated ontology management (Amina and Chris)
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| * [[OBO-Edit progress statistics]]
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| * Michael Schroeder et al. plug-in
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| * [http://sourceforge.net/tracker/?group_id=36855&atid=418257 Sourceforge Bug Tracker]
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| * [http://sourceforge.net/tracker/?group_id=36855&atid=418260 Sourceforge Feature Requests]
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| * [http://sourceforge.net/project/showfiles.php?group_id=36855&package_id=148487 Download the latest OBO-Edit2 beta]
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| ===Organization/Management===
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| *SourceForge clearout done
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| *Possible forthcoming changes to day-to-day editing practices (David, Midori, Chris?)
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| **Creating and using cross-products
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| **Using new relationship types
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| **Integrating QC into editing pipeline
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| ==General Annotation==
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| ===Evidence Codes===
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| * Using the ECO as the primary source (and definition) for evidence codes. The documentation should <em>reflect</em> (not define) the evidence codes found in the ontology. Also, need to make sure that there is a tracker for this.
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| Plan to get some people together to work on it for 2-3 days and fix it (somewhat)
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| * Michelle will be ECO editor
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| * HTP evidence code? (Eurie)
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| * [[Electronically curated flag]] in GAF proposal
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| * New subcodes of IGC will be going into ECO: inferred from system reconstruction (ISR) and inferred from genome cluster (ICL). Currently IGC encompasses more than one type of evidence - it includes both pathway reconstruction/protein complex reconstruction and also operon structure/synteny. In order to be able to more precisely describe which was used we want to have the two new codes. These are currently being used by the Bioinformatics Resource Centers (BRCs). This was discussed on the evidence code mail list and there was no objection. (Michelle)
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| ===Annotation and ontologies===
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| *A (re-)introduction to the new column 16, [[Annotation_Cross_Products]]
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| *Ontological relationships between gene products and functions, processes and components
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| ===GO Database===
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| * APIs
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| ** GHOUL GO Hibernate Object Utility Layer. An API to the GO database for Java programmers
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| ** Lucene indexing
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| * Regular reporting of statistics, sanity checks, and such on the GO database.
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| * New way of calculating the [[Transitive_closure]]
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| ===PAMGO report on successes and some problem annotations from consortium members===
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| * PAMGO terms are in wide use, however they are sometimes being used incorrectly by consortium members. Candace will outline the way the terms should be used, Michelle will outline the problems and suggest some solutions. Also will touch on alternate taxon id resources that we might want to incoroporate. (Candace and Michelle)
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| * Update on loading dual taxon into database/AmiGO. Also will touch on alternate taxon id resources that we might want to incoroporate. (Michelle and Chris?)
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|
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| ==22 OCT AM: Reference Genome 1/2 day==
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| ===Proposed Process: Paul and Kara===
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| # generating homology sets, including protein set generation
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| # new paradigm for making homology inferences
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| # process and implementation for homology set selection, and homology inferences
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|
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| ====Discussion about protein set generation====
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| * Issues:
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| ** incompleteness
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| ** splice forms vs canonical protein
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| ** complete proteome; partial gene predictions
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| ** possible solution: try to work with Swiss Prot?
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| * Regarding gp2protein files: The original aim was to support BLAST server.
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| ** Do we need another file? g2protein? predicted_non_redundant_protein? this file would have just protein??
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| ====new paradigm for making homology inferences====
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| ===Literature-baseed Annotation Consistency and Quality Issues: Pascale===
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| # How to improve documentation
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| # How to address the QC issue
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| # Make working groups for recurrent problems:
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| #* binding
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| #* regulation
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| #* most evidence codes
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| ===Improvement in ontology structure: David===
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| *Examples of ontology changes stemming from Reference Genome annotation
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| === Improvements in annotation depth and breadth: Mike===
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| ==Web presence, Outreach and User Advocacy==
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| ===Outreach===
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| *Short update on Outreach going on throughout the Consortium. Highlights presented by Tanya Berardini (Author submission of annotations - 3 [http://cvsweb.geneontology.org/cgi-bin/cvsweb.cgi/go/meeting/consortium/Montreal2008/OutreachTAIR_PlantPhys_TBerardini.ppt Slides]) and Michelle Gwinn-Giglio (PAMGO outreach and University of Maryland Annotation courses - 6 [http://cvsweb.geneontology.org/cgi-bin/cvsweb.cgi/go/meeting/consortium/Montreal2008/OutreachMGwinnGiglio.ppt Slides]).
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| *Swiss-Prot to do GO annotations (Michael)
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| ===AmiGO 1.6 for Reference Genome (Seth & Amelia)===
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| # Present progress on AmiGO graphical views
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| ===Michael Schroeder will report on new OBO-Edit plugin===
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| ===Resource Usage statistics (Mike)===
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| ===User Support===
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| # Evaluation of helpdesk performance
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| ===GO Papers, Publications and Presentations===
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| # Ref Genome paper status report
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| # AmiGO app. note
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| # News letter impact
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| ==Other items==
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| ===Consortium meetings===
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| *'''Next GOC meeting''' : Coordinate with [http://projects.eml.org/sdbv/events/BiocurationMeeting/index.html Third International Biocurator Meeting], Berlin, April 16-19, 2009?
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| ===Breakout sessions to fit in somehow===
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| * Final preparations for SAB meeting
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| * Amina, Chris and OBO-Edit users (including cross-products)
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| * Pascale, Suzi and reference genome curators
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| Return to [[Consortium_Meetings]] | | Return to [[Consortium_Meetings]] |