Overview of the Gene Ontology and Annotations
TO BE REVIEWED This is a mix of a number of older pages and presentations, including the presentation that Suzi L, Paul and Pascale did at the BC2 meeting in 2017 Need to also check redundancy with http://geneontology.org/docs/go-annotations/
An ontology of Gene Function
The Gene Ontology is a "vocabulary" of gene functions, that contains classes representing biological concepts, and relationships between these concepts.
- Classes: Each representing a biology entity
- Relations: How different entities relate to one another
- Each concept has two definitions:
- logical, i.e. relative to the other concepts. Logical definitions are computable.
An annotation is a statement linking a gene to some aspect of its function (a GO ontology term). Annotations describe:
- How a gene functions at the molecular level
- Where in the cell a gene functions
- What biological processes (pathways, programs) a gene helps to carry out
- Each annotation must be based on evidence, which is recorded as part of the annotation
- Evidence code (type of evidence)
- Reference (published journal article)
Together, the ontology and the annotations make a model of biological knowledge.