PAINT - Apoptosis (Archived): Difference between revisions
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This page captures PANTHER families with annotations to 'execution phase of apoptosis'. Please sign up for a family, and comment after you submit them to the SVN repository. | This page captures PANTHER families with annotations to 'execution phase of apoptosis' GO:0097194). The definition is "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The execution phase ends when the cell has died." | ||
Thus, all signaling events upstream from the effector caspases (those include CASP3, CASP6, CASP7) should *not* be annotated to this term. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) should also not be annotated to this term. See http://en.wikipedia.org/wiki/Caspase and http://en.wikipedia.org/wiki/Apoptosis for general background. | |||
'Please sign up for a family, and comment after you submit them to the SVN repository.' | |||
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Revision as of 11:02, 16 November 2013
This page captures PANTHER families with annotations to 'execution phase of apoptosis' GO:0097194). The definition is "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The execution phase ends when the cell has died." Thus, all signaling events upstream from the effector caspases (those include CASP3, CASP6, CASP7) should *not* be annotated to this term. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) should also not be annotated to this term. See http://en.wikipedia.org/wiki/Caspase and http://en.wikipedia.org/wiki/Apoptosis for general background.
'Please sign up for a family, and comment after you submit them to the SVN repository.'
Family | PTHR ID | Curator | Execution phase of aopoptosis annotation justified? |
cell death activator cide | PTHR12306 | Moni -- committed | |
DNA fragmentation subunit Beta | PTHR13067 | Moni -- committed | |
map-kinase activating death domain protein (madd)/denn/aex-3(c.elegans) | PTHR13008 | Moni | |
caspase | PTHR10454 | Paul | Yes |
calpain | PTHR10183 | Rama | |
mitogen-activated kinase kinase kinase | PTHR24361 | Huaiyu | |
sorting nexin | PTHR10555 | Rama | |
40s ribosomal protein s3a | PTHR11830 | Pascale - committed | No |
akt-related serine/threonine-protein kinase | PTHR24352 | DHL | |
bcl-2 related | PTHR11256 | Huaiyu | |
bcl2/adenovirus e1b 19-kda protein-interacting protein | PTHR12112 | Moni -- need to resolve family name conflict. | |
disulfide oxidoreductase | PTHR22912 | Paul | No |
ephrin | PTHR11304 | Li | |
ets | PTHR11849 | Rama | |
f-box and wd40 domain protein | PTHR22844 | Rama | |
family not named | PTHR18834 | Li | |
family not named | PTHR24025 | Karen | |
group ii pyridoxal-5-phosphate decarboxylase | PTHR11999 | Rama | |
microtubule-associated protein | PTHR13843 | DHL | |
nadh dehydrogenase-related | PTHR22915 | Rama | |
protein arginine n-methyltransferase | PTHR11006 | Pascale | |
protein disulfide isomerase | PTHR18929 | Paul | No |
rbm25 protein | PTHR18806 | Pascale - committed | No |
telomeric repeat binding protein | PTHR21717 | Li | |
tumor protein d52 | PTHR19307 | Karen | |
type i interferon | PTHR11691 | Pascale | No |
u3 small nucleolar rna-associated protein 11 | PTHR12838 | Karen | |
ubiquilin | PTHR10677 | DHL |
Families annotated to children of 'execution phase of apoptosis
Family | PTHR ID | Curator | Execution phase of aopoptosis annotation justified? |
glucagon | PTHR11418 | ||
30s/40s ribosomal protein s3 | PTHR11760 | ||
rho-type gtpase activating protein | PTHR12659 | ||
family not named | PTHR15186 | ||
cop9 signalosome complex subunit 7/dendritic cell protein ga17 | PTHR15350 | ||
myosin light chain kinase-related | PTHR22964 | ||
paraneoplastic antigen | PTHR23095 | ||
translation factor | PTHR23115 | ||
family not named | PTHR24271 | ||
family not named | PTHR24272 | ||
family not named | PTHR24295 | ||
family not named | PTHR24377 | ||
family not named | PTHR32047 |