PTHR10981: Difference between revisions
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*'''Question: '''Organisms that annotate to "lysosome" or other membrane-bound compartments: Can you specify "membrane" or "integral to membrane" in these compartments? | *'''Question: '''Organisms that annotate to "lysosome" or other membrane-bound compartments: Can you specify "membrane" or "integral to membrane" in these compartments? | ||
**'''Curator answer:''' Insert answer here. | **'''Curator answer:''' Insert answer here. | ||
FlyBase: On reviewing this I managed to add a new experimental lysosome annotation for Drosophila from PMID:19028667 but could not specify "membrane" or "integral to membrane" terms from this paper. The authors in this 2009 paper comment, "The exact localization of CLN3 remains undefined despite | |||
examination of its distribution in a number of studies." Susan | |||
==Biological process== | ==Biological process== | ||
Revision as of 12:56, 17 March 2011
This is a list of questions that arose while PAINTing PTHR10981.
Questions for MOD curators
Cellular component
All organisms
- Question: Organisms that annotate to "lysosome" or other membrane-bound compartments: Can you specify "membrane" or "integral to membrane" in these compartments?
- Curator answer: Insert answer here.
FlyBase: On reviewing this I managed to add a new experimental lysosome annotation for Drosophila from PMID:19028667 but could not specify "membrane" or "integral to membrane" terms from this paper. The authors in this 2009 paper comment, "The exact localization of CLN3 remains undefined despite examination of its distribution in a number of studies." Susan
Biological process
Human
- Question: Is there a more specific term than GO:0051453 "regulation of intracellular pH" that can be used based on PMID 10924275, "CLN3 protein regulates lysosomal pH and alters intracellular processing..." which states, "CLN3 protein increases lysosomal pH in cultured human embryonal kidney cells." Should there be a new term?
- Curator answer: Insert answer here.