Panther ID:11559

An error was encountered while uploading these annotations in Excel (.xls) format, so please click here to find the ACHE annotations in text format. This is a plain text GAF file containing suggested annotations for the ACHE family of proteins (PTHR11559) produced by protein family annotators using the PANTHER method, July 2009. Note: Currently, the file has spaces instead of tabs.

There are 2 types of annotations:

• Up-propagation (no species listed): Annotations to hypothetical ancestral proteins showing a consensus parental GOID (column E) and the proteins on which these annotations are based (column H).
• Down-propagation (species listed, following the corresponding up-propagation): Annotations to real proteins based on their descent from the hypothetical ancestors (column H).

Up-propagations: 35

Down-propagations: 1675

Unique GO terms: 33

Organisms represented: 10 (ARATH, CAEEL, CHICK, DANRE, DICDI, DROME, HUMAN, MOUSE, RAT, SCHPO)

General observation: There are a lot of annotations to "cytoplasm" (GO:0005737) and its children, but also to other non-cytoplasmic components of the cell. In this situation, I don't feel comfortable propagating "cytoplasm" annotations except in narrow circumstances, such as single clades.

Problems detected and fixed through annotation of this family:

• A link was added to make "ER lumen" (GO:0005788) an "ER part" (GO:0044432). (SF item 2828065) [1]
• (Pending) Several terms requested to be moved from children of "response to chemical stimulus" to "response to organic substance" (SF item 2830403) [2]

Note: Pending the outcome of SF item 2830403, either or both of the sets of annotations to "response to chemical stimulus" (GO:0042221)" perhaps should instead be annotated to "response to organic substance" (GO:0010033).