Procedure for selection of target genes (Retired): Difference between revisions
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# Enter all ID in the [http://spreadsheets0.google.com/ccc?key=pwOksMOra5uq4vIYjPgefPw Master Table]. The Human Genome Nomenclature Committee's site is a nice source for those IDs, [http://www.genenames.org/cgi-bin/hgnc_search.pl HGNC search tool]. | # Enter all ID in the [http://spreadsheets0.google.com/ccc?key=pwOksMOra5uq4vIYjPgefPw Master Table]. The Human Genome Nomenclature Committee's site is a nice source for those IDs, [http://www.genenames.org/cgi-bin/hgnc_search.pl HGNC search tool]. | ||
# For disease genes, enter the OMIM ID of the disease or a PMID of a paper describing the gene's implication in a disease | # For disease genes, enter the OMIM ID of the disease or a PMID of a paper describing the gene's implication in a disease | ||
# This site is pretty useful for finding all of the identifiers that go in the various columns [http://www.genenames.org/cgi-bin/hgnc_search.pl HGNC Search] | |||
== Disease genes == | == Disease genes == |
Revision as of 16:37, 23 October 2007
Guidelines
- Try to select related genes (same pathway, same disease)
- Check that the gene is not already done (easiest to search by UniProt ID)
- Enter all ID in the Master Table. The Human Genome Nomenclature Committee's site is a nice source for those IDs, HGNC search tool.
- For disease genes, enter the OMIM ID of the disease or a PMID of a paper describing the gene's implication in a disease
- This site is pretty useful for finding all of the identifiers that go in the various columns HGNC Search
Disease genes
Conserved Human-E.coli
- list of genes is in the 'Suggestions' spreadsheet (look for the "conserved Hs-Ec" sheet)
- enter the ensemble ID in YOGY
- find the UniProt ID from the YOGY summary tables
- check the 'master list' to make sure the gene has not previously been selected
Bleeding edge genes
- Recent highlighted articles in your database
- Science Daily
- Medline
- Expasy Spotlight
- other suggestions welcome
Biochemical/signaling pathways
Try picking 5 genes form the same pathway