Provides input for

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Overview and Scope of Use

  • This relation is used in GO-CAMs but not in standard annotation extensions.
  • This relation is intended to connect successive enzymatic reactions in a pathway, i.e. where the product of the upstream activity is the substrate for the downstream activity.
    • When the output molecule of the upstream activity is available in ChEBI, curators should not use this relation, and should instead connect the successive activities via the output molecule: [upstream] has_output [ChEBI] is_input [downstream].
    • When the output molecule is not available (usually a modified protein or RNA), use: [upstream] provides_input_for [downstream].
  • The 'provides input for' relation is used to relate two GO Molecular Functions when:
    • Two Molecular Functions succeed one another directly
    • The output of the first molecular function is an input of the second Molecular Function.
    • The output of the first molecular function is not available in ChEBI.

Annotation Usage Guidelines

    • 'directly provides input' should be reserved to related successive Molecular Functions in GO-CAM models.
    • Usage Examples
      • In glycolysis, triose phosphate isomerase activity (MF) 'directly provides input for' glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (MF).
        • triose phosphate isomerase activity converts dihydroxyacetone phosphate (input) to glyceraldehyde-3-phosphate (output) as part of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase converts glyceraldehyde-3-phosphate (input) to 3-phosphonato-D-glyceroyl phosphate(4−) (output).
        • http://noctua.geneontology.org/editor/graph/gomodel:632cf60a00000208
      • A glucose tansmembrane transporter activity (MF) 'directly provides input for' lactose synthase activity (MF).

Ontology Usage Guidelines

  • This relation is not used in the ontology.

Cross Reference to the Relation Ontology (RO)

directly provides input for

Review Status

Reviewed: Nov 2, 2022 DavidH


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