Provides input for

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Overview and Scope of Use

  • This relation is used in GO-CAMs but not in standard annotation extensions.
  • This relation is intended to connect successive activities, i.e. where the product (output) of the upstream activity is the substrate (input) for the downstream activity, and the product is a macromolecule.
    • When the output molecule of the upstream activity is available in ChEBI, curators should not use this relation, and should instead connect the successive activities via the output molecule: [upstream activity] has_output [ChEBI] is_input [downstream activity].
    • When the output molecule is not available (usually a modified protein or RNA), use: [upstream activity] provides_input_for [downstream activity].
  • The 'provides input for' relation is used to relate two GO Molecular Functions when:
    • The upstream and downstream activities succeed one another directly
    • The output of the first activity is an input of the second activity.
    • The output of the first activity is not available in ChEBI.

Annotation Usage Guidelines

  • What to capture
    • Upstream activities that provide a macromolecular input for a downstream activity.
  • What not to capture
    • Causal connections between molecular activities in which all inputs and outputs are described in ChEBI; instead, connect the successive activities via the output molecule: [upstream activity] has_output [ChEBI] is_input [downstream activity]. For an example, see GO-CAM model with inputs and outputs.

Examples

AKT1 phosphorylates RAC1, creating phosphorylated RAC1 (which is not in ChEBI); phosphorylated RAC1 is then the input (target) for FBXL19, the substrate adaptor for ubiquitination and degradation of RAC1. PMID:23512198

Provides input

GO-CAM model

Ontology Usage Guidelines

This relation is not used in the ontology.

Cross Reference to the Relation Ontology (RO)

provides input for

Review Status

Last reviewed: February 15, 2023

Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken


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