Regulates

WIP

Overview and Scope of Use

• The 'regulates' relation is used to relate two GO Biological Processes (BP) or two GO Molecular Functions (MF) to one another in a causal chain when:
  • the mechanism by which the upstream process or function 'regulates' the downstream process process or function is understood
    • if a process 'regulates' another process, a function in the upstream process 'regulates' a function in the downstream process via an effect on the enabler of the downstream function
    • if a function 'regulates' another function, the upstream function 'regulates' the downstream function via an effect on the enabler of the downstream function
  • the processes or functions are not constitutive and only occur under specific conditions

Annotation Usage Guidelines

The 'regulates' relation is a parent to more specific relations that capture the directionality and proximity of the regulation, e.g. 'positively regulates', 'directly positively regulates', 'indirectly positively regulates'.

GO-CAM

• The 'regulates' relation is a parent to more specific relations that capture the directionality and proximity of the regulation, e.g. 'positively regulates', 'directly positively regulates', 'indirectly positively regulates'.
• When annotating causal relations between Molecular Functions in a GO-CAM, curators should always strive to use one of the following more specific relations:
  • directly positively regulates
  • indirectly positively regulates
  • directly negatively regulates
  • indirectly negatively regulates

Quality Control Checks

• Annotations can be validated using a Shape Expressions (ShEx) representation of allowed relations between ontology terms.

Child Terms

• 'negatively regulates'
• 'positively regulates'

Relations Ontology

regulates

Review Status

• Last Reviewed: October 5, 2022

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