Regulates

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WIP

Overview and Scope of Use

  • The 'regulates' relation is used to relate two GO Biological Processes (BP) in a causal chain when:
    • the mechanism by which the upstream process or function 'regulates' the downstream process process or function is understood
      • if a process 'regulates' another process, a function in the upstream process 'regulates' a function in the downstream process via an effect on the enabler of the downstream function
      • if a function 'regulates' another function, the upstream function 'regulates' the downstream function via an effect on the enabler of the downstream function
    • the processes or functions are not constitutive and only occur under specific conditions

Annotation Usage Guidelines

The 'regulates' relation is a parent to more specific relations that capture the directionality and proximity of the regulation, e.g. 'positively regulates', 'directly positively regulates', 'indirectly positively regulates'.

Standard GO Annotation

GO-CAM

  • The 'regulates' relation is a parent to more specific relations that capture the directionality and proximity of the regulation, e.g. 'positively regulates', 'directly positively regulates', 'indirectly positively regulates'.
  • When annotating causal relations between Molecular Functions in a GO-CAM, curators should always strive to use one of the following more specific relations:
    • directly positively regulates
    • indirectly positively regulates
    • directly negatively regulates
    • indirectly negatively regulates

Ontology Usage Guidelines

This relation is used in the ontology to link biological processes to biological processes. It is also used in to link biological processes to molecular functions under the '[regulation of molecular function]' branch, but note that this branch will be deprecated in 2023.

Relations Ontology

regulates

Review Status

  • Last Reviewed: October 5, 2022

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