Suggestions for RefGen jamboree annotation targets (Archived): Difference between revisions

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Revision as of 16:43, 17 December 2009

Please note here any genes that you think might be suitable for a Reference Genome jamboree.

All groups that participate in the jamboree should note the amount of literature that is available for each proposed target. Therefore the aim would be to select two targets for a jamboree that have the widest spread of literature across all participating groups.

In addition, please indicate your preferred date for the RefGen call, by visiting: http://www.doodle.com/a4h2u7hdcmqieiir

Target Gene Name PPOD URL Arabidopsis ID & papers Dicty ID & papers Drosophila ID & papers C.elegans ID & papers Chicken ID & papers E.coli ID & papers Human ID & papers Mouse ID & papers Rat ID & papers S.cerevisiae ID & papers S.pombe ID & papers Zebrafish ID & papers
WNT4 (Ligand for frizzled family of transmembrane receptors. Probable developmental protein. Possible signaling molecule which affects the development of discrete regions of tissues) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL5001 none none none WB:WBGene00000857 (cwn-1 · K10B4.6) · UniProtKB:P34888

~17 papers

(UniProtKB:P49337)~10 (UniProtKB:P56705)~70 (MGI:98957) ~65 (RGD:621348) ~40 (no ortholog) 0 ZDB-GENE-980526-352 wnt4a Q1RLW9 ~16; ZDB-GENE-000411-1 wnt4b Q9IAU3 ~2
SLIT2 (molecular guidance cue in cellular migration) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL916 none none (UniProtKB:P24014, FB:FBgn0003425) ~100 WB:WBGene00004854 (F40E10.4 · slt-1) · UniProtKB:Q20204

~27 papers

(UniProtKB:Q90WZ2,

UniProtKB:Q90XG2, UniProtKB:Q90Z44)

~10 papers
(UniProtKB:O94813) ~60 (MGI:1315205) ~35 (RGD:69310) ~40 (no ortholog) 0 UniProtKB:Q3S2J2 · ZFIN:ZDB-GENE-030722-3 (slit1a) ~11, UniProtKB:Q3Y6S4 · ZFIN:ZDB-GENE-030722-4 (slit1b) ~8, UniProtKB:Q9DE36 · ZFIN:ZDB-GENE-010306-3 (slit2) ~12, UniProtKB:Q9DE37 · ZFIN:ZDB-GENE-010306-4 (slit3) ~11
NFX1 (Nuclear transcription factor). In mammals may be involved in regulating duration of an inflammatory response) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL3955 (TAIR:AT1G10170)(UniProtKB:Q9SY59) ~8 DDB_G0293590 : 1 HTP (UniProtKB:P40798, FB:FBgn0001978) ~3 WB:WBGene00007048 (C16A3.7 · tag-182) · UniProtKB:Q18034

0 papers

(GenBank:XP_418890)

No papers

(UniProtKB:Q12986) ~8 (MGI:1921414) ~ 2 (RGD:1310277) - 0 (SGD:S000004968) 7 No ortholog in set
ATF6B (Cyclic AMP-dependent transcription factor ATF-6 beta) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL4962 none none (UniProtKB:Q8SX87, FB:FBgn0033010) 0 WB:WBGene00000222 (F45E6.2 · atf-6) · UniProtKB:Q20435 (F45E6.2 · atf-6)

~9 papers

No ortholog (UniProtKB:Q99941) ~40 (MGI:105121) ~ 3 (RGD:1303317) - 0 (no ortholog) 0 Q5RH85 si:ch211-199m3.9 ZDB-GENE-041014-328 ~0
SIR2 (NAD-dependent histone deacetylase SIR2 of the Sirtuin family involved in regulation of lifespan, EC=3.5.1.-) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/Para1362 (TAIR:AT5G55760) (UniProtKB:Q9FE17) ~2 (UniProtKB:Q54GV7): DDB_G0289967 (sir2D): none (UniProtKB:Q9VK34, FB:FBgn0024291) ~11 WB:WBGene00004800 (R11A8.4 · sir-2.1) · UniProtKB:Q21921 (R11A8.4 · SIRT1_CAEEL · sir-2.1)

~40 papers

(UniProtKB:Q68BG0)1 paper (UniProtKB:P75960) (UniProtKB:Q96EB6) ~115 (MGI:2135607) ~ 49 (RGD:1308542) ~36 (SGD:S000005429; SGD:S000005936; SGD:S000005551; SGD:S000002599; SGD:S000002200) ~640 [even if we chose to do JUST SIR2 and not the related 4 proteins, that would still be 592 papers] (UniProtKB:O94640) ~1 UniProtKB:Q7ZVK3 · ZFIN:ZDB-GENE-030131-1028 (sirt2) ~0, UniProtKB:A1L2B7 · ZFIN:ZDB-GENE-070112-1762 (sirt3) ~0, UniProtKB:Q1LWD1 ZDB-GENE-061207-46 (si:dkey-103i16.6) ~0, ZFIN:ZDB-GENE-041010-65 (zgc:103539) UniProtKB:Q5XJ86 ~0, UniProtKB:Q6DHI5 · ZFIN:ZDB-GENE-040718-349 (sirt5) ~0, UniProtKB:Q6IQK0 · ZFIN:ZDB-GENE-031007-2 (sirt6) ~0,
ELAC2 (tRNA 3'-processing endonuclease; defects are involved in prostate cancer) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL1557 WB:WBGene00001983 (hoe-1 · E04A4.4) · UniProtKB:O44476

1 paper

(UniProtKB:Q9BQ52) ~6 (SGD:S000001787) ~13 ZFIN:ZDB-GENE-041111-227 (im:7145112) · UniProtKB:Q6DG69 ~0
SURF1 (involved in assembly of cytochrome c oxidase; defects are a cause of Leigh syndrome) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL1594 WB:WBGene00004787 · UniProtKB:Q9N5N8

0 papers

(UniProtKB:Q15526) ~30 (SGD:S000003344) ~41 UniProtKB:A5WUL6 · ZFIN:ZDB-GENE-041108-2 (surf1) ~1
NIPBL (involved in sister chromatid cohesion; defects are the cause of Cornelia de Lange syndrome type 1 (CDLS1)) http://ppod.princeton.edu/cgi-bin/ppod.cgi/GO3/OrthoMCL1223 WB:WBGene00004166 (Y43H11AL.3 · pqn-85) · UniProtKB:Q95XZ5

2 papers

(UniProtKB:Q6KC79)~19 (SGD:S000002588) ~ 45 ENSEMBL:ENSDARP00000081088 ZDB-GENE-030131-6070 (nipblb) ~1, UniProtKB:A2BGN3 ZDB-GENE-060526-121 (nipbla) 0