Swiss-Prot keywords SPKW2GO

Swiss-Prot entries are assigned keywords manually based on literature and sequence analysis checks by curators. In addition, TrEMBL entries are assigned keywords automatically from two sources;

   *initially, as the TrEMBL entry is first created, based on keywords in the nucleotide sequence entry

   *subsequently, during automatic annotation, by two programs

         RuleBase – which uses manually curated rules
         Spearmint – which is an automatic system based on decision trees

Keywords are mapped to corresponding GO terms in the SPKW2GO file, which was originally constructed manually by MGI curators and is now maintained by the UniProtKB-GOA team at EBI. The mappings are then transitively assigned at each UniProtKB-GOA release. GO annotations using this technique will receive the evidence code Inferred from Electronic Annotation (IEA).

This method has been evaluated at 91-98% accurate (Camon et. al., 2005).

The SPKW2GO mapping file is available at: http://www.geneontology.org/external2go/spkw2go.