Talk:2010 GO camp Annotation of complexes issues

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  • Could we possibly use IntAct to perform annotations

IntAct: a complex is something that can be purified , ideally has a function
GO: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

Q: do transient complexes qualify?
A: (Sandra) grey area- for example cdk/cyclin is considered a complex; rather a case-by case basis

Q: How are different species captured?
A: (Sandra) right now all spp are kept separate; look for experimental support for the complex. NOT propagating complexes.

Q: If we annotate to complexes, how will we annotate the individual subunits to the MF/BP?
A: (Emily):
A: (Sandra)