Talk:2010 GO camp Annotation of complexes issues

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Conference call: April 27, 2010

  • Could we possibly use IntAct to perform annotations ?

IntAct: a complex is something that can be purified , ideally has a function
GO: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

Q: do transient complexes qualify?
A: (Sandra) grey area- for example cdk/cyclin is considered a complex; rather a case-by case basis

Q: How are different species captured?
A: (Sandra) right now all spp are kept separate; look for experimental support for the complex. NOT propagating complexes.

Q: If we annotate to complexes, how will we annotate the individual subunits to the MF/BP?
A: (Emily):
A: (Sandra)

Q: Will IntAct be able to support all MODs?

Q: Are there other resources we should be looking into?


ACTION ITEM [Sandra, Harold]: Produce mock ups to show how using Interaction databases would be used for GO. Please discuss how ALL MODs could be included (if they can't, what they would do).



Next meeting: We'll at definition of complexes (they should probably be defined by function rather than composition); provide guidelines about how CC -complex terms should be created.

  • We need to propose a solution for interactions that regulate some MF/BP, but not necessarily part of the complex. Right now people might (a) create a new complex term; (b) use colocalizes with.