Wnt signaling Pathway (Archived): Difference between revisions

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#* wnt7, wnt16
#* wnt7, wnt16
#* wnt10
#* wnt10
#Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
# frizzled: PTHR11309
# frizzled: PTHR11309
#* According to Panther, there are at least 7 distinct subfamilies.  
#* According to Panther, there are at least 7 distinct subfamilies.  
Line 17: Line 18:
#* frz3
#* frz3
#* frz6 (O60353)
#* frz6 (O60353)
#Transmembrane proteins that are receptors for the Wnt signaling proteins.
#* SFRP
#* SFRP
#Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
#Dishevelled: PTHR10878
#Dishevelled: PTHR10878
#* dvl1, dvl2, dvl3
#* dvl1, dvl2, dvl3
#Cytoplasmic phosphoproteins, role in cytoplasmic signal transcduction of Wnt signaling pathway.
#* dixdc1
#* dixdc1
#Axin: PTHR10845:AN318
#Axin: PTHR10845:AN318
#* Subfamily of the RGS (Regulators of G-protein signaling)
#* Subfamily of the RGS (Regulators of G-protein signaling)
#* Axin1, axin2
#* Axin1, axin2
# LRP: PTHR10529
#Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
#* Probable co-receptor together with Frizzled for Wnt
#* LRP: PTHR10529
#* Rather large family; we probably need to select one or a few subfamilies.  
#Probable co-receptor together with Frizzled for Wnt
#beta-catenin: PTHR23315
#Rather large family; we probably need to select one or a few subfamilies.  
#* beta-catenin: PTHR23315
The subtree to which beta-catenin belongs seems okay
The subtree to which beta-catenin belongs seems okay
#Intracellular cytoskeleton, role in structure of adherens junction.

Revision as of 05:39, 8 June 2010

Wnt receptor
Wnt receptor

Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway

  1. wnt: PTHR12027: 6 distinct subfamilies
    • wnt1, wnt3
    • wnt2, wnt5
    • wnt4, wnt8, wnt9, wnt11
    • wnt6
    • wnt7, wnt16
    • wnt10
  2. Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
  3. frizzled: PTHR11309
    • According to Panther, there are at least 7 distinct subfamilies.
    • frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
    • frz5, frz8 (Q9H461,
    • frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
    • frz3
    • frz6 (O60353)
  4. Transmembrane proteins that are receptors for the Wnt signaling proteins.
    • SFRP
  5. Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
  6. Dishevelled: PTHR10878
    • dvl1, dvl2, dvl3
  7. Cytoplasmic phosphoproteins, role in cytoplasmic signal transcduction of Wnt signaling pathway.
    • dixdc1
  8. Axin: PTHR10845:AN318
    • Subfamily of the RGS (Regulators of G-protein signaling)
    • Axin1, axin2
  9. Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
    • LRP: PTHR10529
  10. Probable co-receptor together with Frizzled for Wnt
  11. Rather large family; we probably need to select one or a few subfamilies.
    • beta-catenin: PTHR23315

The subtree to which beta-catenin belongs seems okay

  1. Intracellular cytoskeleton, role in structure of adherens junction.